Latest publications by the lab members

2025

• February 28, 2025

  Reduced plasma levels of GM-CSF is a common feature of Schistosoma mansoni-infected school-aged children

  Severin Donald Kamdem, Leonel Meyo Kamguia, Alim Oumarou, Bernard Marie Zambo Bitye, Katie Lennard, Frank Brombacher, Thomas Spangenberg, Claudia Demarta-Gatsi, Justin Komguep Nono

  https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1474575/full
• February 10, 2025

  Interdisciplinary symposium on challenges and opportunities for vaccines: A comprehensive approach of current and future vaccine strategies to improve vaccine effectiveness in complex chronic infectious contexts

  Alex S. Siebner, Marrium Habib, Vanesa Osmani, Ayola Akim Adegnika, Christian Bogdan, Minka Breloer, Alison Elliott, Anahita Fathi, Greet Hendrickx, Justin Komguep Nono, Roland Lang, Johannes U. Mayer, Benjamin Mordmüller, Esther Ndungo, Ulrike Protzer, Maria Yazdanbakhsh, Stefanie J. Klug, Clarissa Prazeres da Costa, Meral Esen

  https://www.sciencedirect.com/science/article/pii/S2590136225000099
• February 03, 2025

  Diagnostic, prognostic, and therapeutic potentials of gut microbiome profiling in human schistosomiasis: A comprehensive systematic review

  Martin Gael Oyono, Sebastien Kenmoe, Jean Thierry Ebogo Belobo, Leonel Javeres Mbah Ntepe, Mireille Kameni, Leonel Meyo Kamguia, Thabo Mpotje, Justin Komguep Nono*

  https://doi.org/10.1371/journal.pntd.0012844

2024

• November 01, 2024

  Intensify praziquantel administration to reverse vaccine hyporesponsiveness in LMICs?

  Justin Komguep Nono

  https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(24)00356-5/fulltext?rss=yes
• May 22, 2024

  Cysteinyl leukotriene receptor-1 as a potential target for host-directed therapy during chronic schistosomiasis in murine model.

  Mosala P, Mpotje T, Abdel Aziz N, Ndlovu H, Musaigwa F, Justin Komguep Nono, Brombacher Frank.

  https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1279043/full
• March 21, 2024

  Harnessing Schistosoma-associated metabolite changes in the human host to identify biomarkers of infection and morbidity: Where are we and what should we do next?

  Mireille Kameni, Fungai Musaigwa, Leonel Meyo Kamguia, Severin Donald Kamdem, Gladice Mbanya, Poppy H. L. Lamberton, Justin Komguep Nono

  https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0012009

2023

• April 24, 2023

  Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

  Nicola Caldwell, Rana Afshar, Beatriz Baragaña, Amaya L. Bustinduy, Conor R. Caffrey, James J. Collins, Daniela Fusco, Amadou Garba, Mark Gardner, Mireille Gomes, Karl F. Hoffmann, Michael Hsieh, Nathan C. Lo, Case W. McNamara, Justin Komguep Nono, Gilda Padalino, Kevin D. Read, Meta Roestenberg, Thomas Spangenberg, Sabine Specht, and Ian H. Gilbert*

  https://pubs.acs.org/doi/full/10.1021/acsinfecdis.3c00081

2022

• February 14, 2022

  Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses

  Musaigwa F,Kamdem SD, Mpotje T, Mosala P, Aziz NA, Herbert DR, Brombacher F, Nono JK

  https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010327

2021

• December 12, 2021

  Praziquantel Treatment of Schistosoma mansoni Infected Mice Renders Them Less Susceptible to Reinfection.

  Nono JK, Mpotje T, Mosala P, Aziz NA, Musaigwa F, Hlaka L, Spangenberg T and Brombacher F

  http://journal.frontiersin.org/article/10.3389/fimmu.2021.748387/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Immunology&id=748387
• November 08, 2021

  IL-4i1 regulates immune protection during Mycobacterium tuberculosis infection

  Hlaka L, Ozturk M, Chia JE, Jones SS, Pillay S, Poswayo SKL, Mpotje T, Nono JK, Simelane S, Parihar SP, Roy S, Suzuki H, Brombacher F, Guler R.

  med.ncbi.nlm.nih.gov/34739044/
• August 10, 2021

  Influence of schistosomiasis on host vaccine responses

  Nono JK, Kamdem SD, Musaigwa F, Nnaji CA, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/34389214/

2020

• June 30, 2020

  Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models

  Nono JK, Fu K, Mpotje T, Varrone G, Aziz NA, Mosala P, Hlaka L, Kamdem SD, Xu D, Spangenberg T, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/32606340/
• May 08, 2020

  Expansion of Host Regulatory T Cells by Secreted Products of the Tapeworm Echinococcus multilocularis

  Nono JK, Lutz MB, Brehm K.

  https://pubmed.ncbi.nlm.nih.gov/32457746/
• February 17, 2020

  An ultrasound-based referential of body height-adjusted normal liver organometry in school children from Bokito in rural Cameroon

  Kamdem SD, Kuemkon EM, Kamguia LM, Tchanana GK, Konhawa F, Nche F, Oumarou A, Hamza M, Essomba RG, Kengne M, Ondigui BE, Assoumou MCO, Brombacher F, Nono JK.

  https://pubmed.ncbi.nlm.nih.gov/32066761/

2019

• December 03, 2019

  Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon

  Kamdem SD, Konhawa F, Kuemkon EM, Meyo Kamguia L, Tchanana GK, Nche F, Oumarou A, Hamza M, Ouratou Y, Tcheutchoua MN, Ghislain Essomba R, Ngogang MP, Kengne M, Netongo PM, Ondigui BE, Okomo Assoumou MC, Brombacher F, Nono JK.

  https://pubmed.ncbi.nlm.nih.gov/31849991/

2018

• Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

  Guler R, Mpotje T, Ozturk M, Nono JK, Parihar SP, Chia JE, Abdel Aziz N, Hlaka L, Kumar S, Roy S, Penn-Nicholson A, Hanekom WA, Zak DE, Scriba TJ, Suzuki H, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/30542107/

• IL-4Rα-expressing CD11c+ cells contribute to driving optimal cellular responses during Schistosoma mansoni infection in mice

  Ndlovu H, Nono JK, Nieuwenhuizen NE, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/30500088/
• December 18, 2018

  Interleukin-4 Receptor Alpha Expressing B Cells Are Essential to Down-Modulate Host Granulomatous Inflammation During Schistosomasis

  Ndlovu H, Nono JK, Abdel Aziz N, Nieuwenhuizen NE, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/30619289/
• November 28, 2018

  Host Regulators of Liver Fibrosis During Human Schistosomiasis

  Kamdem SD, Moyou-Somo R, Brombacher F, Nono JK.

  https://pubmed.ncbi.nlm.nih.gov/30546364/
• October 31, 2018

  The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections

  Abdel Aziz N, Nono JK, Mpotje T, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/30379806/
• October 09, 2018

  Schistosomiasis Burden and Its Association With Lower Measles Vaccine Responses in School Children From Rural Cameroon

  Nono JK, Kamdem SD, Netongo PM, Dabee S, Schomaker M, Oumarou A, Brombacher F, Moyou-Somo R.

  https://pubmed.ncbi.nlm.nih.gov/30356757/

2017

• October 03, 2017

  IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases

  Hurdayal R, Ndlovu HH, Revaz-Breton M, Parihar SP, Nono JK, Govender M, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/28916732/
• August 21, 2017

  Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha

  Nono JK, Ndlovu H, Aziz NA, Mpotje T, Hlaka L, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/28827803/
• June 26, 2017

  Interleukin-4 receptor alpha is still required after Th2 polarization for the maintenance and the recall of protective immunity to Nematode infection

  Nono JK, Ndlovu H, Abdel Aziz N, Mpotje T, Hlaka L, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/28651009/
• April 01, 2017

  IL-13-Mediated Regulation of Learning and Memory

  Brombacher TM, Nono JK, De Gouveia KS, Makena N, Darby M, Womersley J, Tamgue O, Brombacher F.

  https://pubmed.ncbi.nlm.nih.gov/28202615/

2016

• October 13, 2016

  Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions

  Vendelova E, Camargo de Lima J, Lorenzatto KR, Monteiro KM, Mueller T, Veepaschit J, Grimm C, Brehm K, Hrčková G, Lutz MB, Ferreira HB, Nono JK.

  https://pubmed.ncbi.nlm.nih.gov/27736880/
• June 01, 2016

  In vitro culture of Mesocestoides corti metacestodes and isolation of immunomodulatory excretory-secretory products

  E Vendelova, G Hrčková , M B Lutz, K Brehm, J K Nono

  https://pubmed.ncbi.nlm.nih.gov/27120409/

2014

• January 02, 2014

  EmTIP, a T-Cell immunomodulatory protein secreted by the tapeworm Echinococcus multilocularis is important for early metacestode development

  Nono JK, Lutz MB, Brehm K.

  https://pubmed.ncbi.nlm.nih.gov/24392176/

2012

• Excretory/secretory-products of Echinococcus multilocularis larvae induce apoptosis and tolerogenic properties in dendritic cells in vitro

  Nono JK, Pletinckx K, Lutz MB, Brehm K.

  https://pubmed.ncbi.nlm.nih.gov/22363826/